Blood+, pronounced as "Blood Plus", is an anime series produced by Production I.G and Aniplex and directed by Junichi Fujisaku. The series premiered in Japan on Sony's anime satellite channel, Animax, as well as on terrestrial networks such as MBS, TBS, and RKB on October 8, 2005. The final episode aired on September 23, 2006. Blood+ is licensed for international distribution in several regions through Sony Pictures' international arm, Sony Pictures Television International (SPTI).
Blood+ was inspired by the 2000 anime film Blood: The Last Vampire; however, there are only a few allusions and basic elements from the film. Fujisaku has been involved with both works, including acting as the director for Blood+ and writing the novelization of Blood: The Last Vampire.
Under the care of her adoptive family, Saya Otonashi has been living the life of an anemic amnesiac, but otherwise ordinary schoolgirl. However, her happy life is shattered when she is attacked by a Chiropteran, learning that she is the only one who can defeat them. Armed with her special katana, Saya embarks on a journey with her family, allies, and her chevalier Haji, to rid the world of the Chiropteran threat and recover her identity. The course of the journey reveals the background history of the Chiropterans and Saya's past, which extends into the mid-19th century.
The series is initially set in September 2005 Okinawa City (Koza), on Okinawa Island, near the US Kadena Air Base. Over the course of the series, Saya travels across the world, from Japan to Vietnam, Russia, France and finally the USA, fighting Chiropterans.